Biodata

Work Experience

Post Doctoral Research Associate, April 2010 - Present

Center for Advanced Biotechnology, Biomedical Engineering, Boston University

Research

Understanding the deleterious effects of antibiotics on mammalian cells. The ultimate goal is to evaluate the long-term effects of antibiotics on mammalian cells and determine if prolonged usage would lead to mutagenesis using molecular biology techniques including RT²-PCR, genomic and mitochondrial DNA sequencing and microarray analysis on primary cells and in vivo mice studies.

Education

Ph.D., Electrical and Computer Engineering, March 2010
Department of Electrical and Computer Engineering and A. J. Drexel Plasma Institute
Drexel University, Philadelphia, Pennsylvania;
Thesis Topic: “Mechanism of Interaction of Non-Thermal Plasma with Living Cells” (interdisciplinary research project between Department of Electrical and Computer Engineering, A. J. Drexel Plasma Institute, Department of Biochemistry and Department of Mechanical Engineering and Mechanics).
Advisor: Dr. Gary Friedman, Department of Electrical and Computer Engineering

Bachelor of Engineering, Electrical Engineering, June 2003
Department of Electrical Engineering, Veermata Jijabai Technological Institute (VJTI),
University of Mumbai, Mumbai, India.
Thesis Topic: "Electrical and Heat Flow Simulation of MEMS structures using SPICE" (Project carried out in collaboration with Reliability Engineering Department, IIT Mumbai),
 

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Professional Experience

1. Post Doctoral Research Associate, April 2010 - Present, Department of Biomedical Engineering, Boston University, Boston, Massachusetts

2. Graduate Research Fellow, April 2005 – Mar 2010, Department of Electrical and Computer Engineering, Drexel University, Philadelphia, Pennsylvania

3. Teaching assistant, January 2006 – Dec 2009, Department of Electrical and Computer Engineering, Drexel University, Philadelphia, Pennsylvania

4. Teaching assistant, Sep 2004 – Dec 2004, Department of Physics, Drexel University, Philadelphia, Pennsylvania

5. Officer, Dealer Development, Dec 2003-April 2004, Tata Motors Limited, Mumbai, India

6. Graduate Engineer Trainee, Jun 2003-Nov-2003, Tata Motors Limited, Pune, India

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Fields of research

1. Non-Thermal Plasma Medicine.

2. Molecular Biology.

3. Applications of Non-Thermal atmospheric pressure discharges in medicine and biology;

4. Atmospheric pressure cold plasma technology with emphasis on dielectric barrier discharges and their interactions with cells and living tissue using advanced molecular biology techniques;

5. Toxicity and efficacy of sterilization of non-thermal plasma treatment of intact and wounded tissue (in-vivo studies using survival and non-survival porcine models)

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Collaboration

1. A. J. Drexel Plasma Institute;

2. Department of Biochemistry and Molecular Biology, Drexel University College of Medicine;

3. Department of Mechanical Engineering ;

4. Department of Surgery, Drexel University College of Medicine

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Selected Journal Publications

1. Effects of Non-Thermal Plasma on Mammalian Cells, S. Kalghatgi, C. Kelly, E. Cerchar, B.Torabi, O. Alekseev, A. Fridman, G. Friedman, J. Azizkhan-Clifford, PLoS ONE, 2010. 6(1): e16270. doi:10.1371/journal.pone.0016270

2. Non-Thermal Plasma Induces Apoptosis in Melanoma Cells via Production of Intracellular Reactive Oxygen Species, R. Sensenig^*, S. Kalghatgi^*,  E. Cerchar, B. Torabi, G. Fridman, A. Shereshevsky, K. Arjunan, E. Podolsky,  A. Fridman, G. Friedman,  J. Azizkhan-Clifford, A. Brooks, Annals of Biomedical Engineering, Feb 2011, 39 (2): p 674 - 687 *Both authors contributed equally to the work.

3. Endothelial Cell Proliferation is Enhanced by Low Dose Non-Thermal Plasma Through Release of Fibroblast Growth Factor - 2, S. Kalghatgi, Gary Friedman, Alexander Fridman, Alisa Morss Clyne. Annals of Biomedical Engineering, Mar 2010, 38 (3): p 748 -757.

4. Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. N. Vasilets, A. Gutsol, A. Fridman, G. Friedman, IEEE Transactions on Plasma Science, Volume 35, Issue 5, Part 2, Oct. 2007, pp. 1559-1566.

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Best paper awards

1. Best Student Paper Award, 36th IEEE International Conference on Plasma Science, June 15 - 19, 2008, Congress Center Karlsruhe, Germany

2. Best paper award, "Technology with the Highest Translational Potential", The Translational Research in Biomedical Engineering Competition,  Drexel University, Philadelphia, October 26, 2007 (co-author);

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Conference travel grant awards

1. IEEE Student Travel Award, 17th IEEE International Conference on Plasma Science, Jun 29th-Jul 2nd 2009, Washington D. C

2. IEEE Student Travel Award, 36th IEEE International Conference on Plasma Science, May 31st - Jun 4th 2009, San Diego, California

3. NSF Student Travel Award to attend the 61st Gaseous Electronics Conference, Oct 13th-17th 2008, Dallas, Texas

4. NSF Student Travel Award to attend Gordon Research Conference on Plasma Processing Science, Jul 13th-18th 2008, Mt. Holyoke, South Hadley, Massachusetts

5. 2007 Drexel University Lee Smith Travelling Fellow;

6. IEEE Student Travel Award, 34th IEEE International Conference on Plasma Science, Albuquerque New Mexico, Jun15th-Jun19th 2007 

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Honors and awards

1. Highly Commended Citation for the 2010 Drexel University Best Dissertation Award

2. Highly Commended Citation for the 2010 Drexel University Excellence in Research Award

3. Honorable mention for the PhD level Student Poster Competition at the ASME 2009 Summer Bioengineering Conference, Jun 17th - Jun 21st 2009. Lake Tahoe, CA, USA

4. Highly Commended Citation for the 2009 Drexel University Excellence in Research Award

5. Invited Talk at the 36th IEEE International Conference on Plasma Science, May 31st - Jun 4th 2009, San Diego, California

6. Drexel University 2008-09 George Hill Jr. Endowed Fellow

7. Finalist for the Student Paper Excellence Award at the 61st Gaseous Electronics Conference, Oct 13th-17th 2008, Dallas, TX, USA

8. Highly Commended Citation for the 2008 Drexel University Excellence in Research Award

9. Nominated for 2008 Drexel University Excellence in Teaching Award

10. Finalist for Best Student Paper Award at the 35th IEEE International Conference on Plasma Science, Albuquerque, New Mexico, Jun 16th-22nd 2007

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Skills

1. Laboratory Skills: RT2-PCR, Microarrays, Genomic Sequencing, DNA/RNA Extraction, si/sh RNAi assays, Plasmid DNA extraction, Gel Electrophoresis, Immunoblotting (Western Blots, Immunofluorescence, ELISA’s, Cell Culture,  Colorimetric and Fluorometric 96-well plate reader assays, Cell Proliferation and Migration Assays, Apoptosis (TUNEL, Caspase Cleavage, Annexin V/PI, Flow Cytometry, FACS analysis, Fluorescence Microscopy, Cytotoxicity Assays, Lipid Peroxidation Assays, Comet Assay, in-vivo wound toxicity and wound sterilization (porcine models), FTIR-ATR, SEM.

2. Software Tools: GraphPad Graphing and Statistical Analysis, Protein Quantification, Flow Cytometry, Gel Imaging, MS Office, MATLAB, Maple, Cadence PSpice, ImagePro Imaging Systems

3. Research Writing: Journal and Conference manuscripts, IRB and IACUC protocols, grant proposals, and patents.

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Service

1. Treasurer of the Graduate Student Association at Drexel University, Jun 2008 – Jun 2009;

2. Vice-President of the Engineering Graduate Association at Drexel University, Jun 2006 – Jun 2008;

3. Secretary of the Engineering Graduate Association at Drexel University, Jun 2005 – Jun 2006;

4. Reviewer for Institute of Electrical and Electronic Engineers, Transactions on Plasma Science (IEEE TPS);

5. Reviewer for the Plasma Medicine Journal.

6. Mentor, Drexel University RET Program, Summer 2005, Summer 2006 and Summer 2008.

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Professional memberships

1. Student member, Institute of Electrical and Electronic Engineers (IEEE), 2004-present;

2. Student member, American Association for the Advancement of Science (AAAS), 2008-present;

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