Dr. Sameer Kalghatgi

           

Curriculum Vitae

SAMEER KALGHATGI

77 Crescent St, Apt 3 • Waltham, MA 02453 • Tel: (267) 231 6595 • sameerk@bu.edu

www.sameerkalghatgi.com

 

SENIOR SCIENTIST

Enthusiastic bioengineer with post doctoral experience having extensive hands-on skills in mammalian cell culture, stem cells, molecular cell biology, biochemistry, systems biology, immunology, signal transduction & animal models along with experience in conducting hypothesis driven multidisciplinary research is looking to lead R&D activities in drug discovery, pharmaceuticals and therapeutics at a major biotechnology firm.

 

SUMMARY

·   Independent and innovative worker capable of working independently or in a team-centered multidisciplinary environment. Critical thinker with excellent analytical, organizational & project management skills along with a demonstrated ability to acquire and apply scientific knowledge and techniques rapidly.

·   Independently setup a tissue culture and molecular biology lab to successfully lead a project on investigating the deleterious effects of common antibiotics on human cells using an integrated cellular-systems biology approach.

·   Established transgenic and wild-type mice models to understand the physiological effects of acute and long-term antibiotic treatment and to develop a clinical solution to reduce or eliminate the detrimental effects of antibiotics.

·   Excellent oral and written communication skills as evidenced by the various invited and contributed talks at international conferences and published first and co-authored papers in leading peer-reviewed journals.

 

SKILLS

·   Adept in various biological techniques like mammalian cell culture, multi-parameter flow cytometry, FACS analysis, confocal and fluorescence microscopy; immunologic techniques including ELISA, gel electrophoresis, western blotting & immunofluorescence; multiplexed assays, RNAi gene knockdown, PCR, microarrays, DNA sequencing, DNA/RNA extraction, phenotypic characterization, signal transduction.

·   Proficient in low, medium and high throughput cell-based assays for evaluating DNA damage, drug toxicity, cellular toxicity, oxidative stress, metabolism, mitochondrial function, proliferation & migration, apoptosis, angiogenesis.

·   Highly skilled in establishing primary and immortalized cell lines including mouse & human ES/iPS cells.

·   Extensive experience in designing and implementing wild-type and transgenic murine and porcine animal models.

·   Trained in protein purification, colorimetric and fluorimetric assays, spectroscopy, HPLC and SEM.

 

EDUCATION

Drexel University, Philadelphia PA                                                                                                          2004 – 2010

Ph. D., Electrical and Computer Engineering, Mar 2010

Advisor: Dr. Gary Friedman (ECE)

Research Interests: Non-Thermal Atmospheric Pressure Plasma, DNA damage and repair, Interaction of Non-thermal Plasma with Cells, Plasma Medicine, and Clinical Applications of Non-Thermal Plasma like Blood Coagulation, Apoptosis, Angiogenesis and Wound Healing

Dissertation: “Mechanisms of Interaction of Non-Thermal Plasma with Living Cells”

Dissertation Committee: Dr. Alex Fridman, Dr. Jane Azizkhan-Clifford, Dr. Alisa Morss Clyne, Dr. Timothy Kurzweg, Dr. Adam Fontecchio

Veermata Jijabai Technological Institute (VJTI), Mumbai, India                                                              1999 – 2003

Bachelor of Engineering (BE), Electrical Engineering, Jun 2003

Thesis: “Electrical and Heat Flow Simulation of MEMS structures using SPICE.

 

WORK EXPERIENCE

Boston University, Department of Biomedical Engineering                                                              4/2010 – Present

Post Doctoral Research Associate with Dr. James Collins

·   Investigated the underlying biological mechanisms of action of antibiotics on mammalian cells both in vitro and in vivo by studying DNA damage, oxidative stress, up/down regulation of key genes involved in antioxidant defenses, mitochondrial energy metabolism & mitochondrial dysfunction using advanced techniques in tissue culture, molecular cell biology, systems biology and biochemistry. Additionally, using qPCR and microarrays successfully studied the antibiotic induced changes in transcription at the whole genome level in mammalian cells.

·   Closely involved in the design & implementation of novel cell culture based experiments to validate the predictions made by computational studies and mathematical modeling of combinatorial drug therapy for cancer treatment

 

RESEARCH EXPERIENCE

Drexel University, ECE Department and                                                                        9/2004 – 3/2010

Graduate Research Fellow with Dr. Gary Friedman

A. J. Drexel Plasma Institute, Philadelphia    Research Fellow, PhD Candidate        5/2006 – 3/ 2010

·         Independently investigated the biological and physical mechanisms of interaction of non-thermal plasma with mammalian cells. Additionally, using RNAi and advanced molecular biology techniques, studied the DNA repair pathways in response to damage induced by oxidative stress due to non-thermal plasma treatment.

·         Took over the lead on a floundering project and successfully investigated the biological and cellular mechanisms induction of apoptosis in melanoma cells by electrical non-thermal plasma treatment by using various techniques such as Annexin-V/PI, Caspase cleavage, TUNEL® and multi-parameter flow cytometry to develop non-thermal plasma as a novel clinical device for melanoma cancer treatment.

·         Investigated the underlying mechanisms of plasma induced proliferation in endothelial cells to develop plasma as a potential therapy for promotion or inhibition of endothelial cell mediated angiogenesis, which is an important target for treating diseases where there is poor (chronic wounds) or abnormal (malignancies) vascularization.

·         Studied and discovered the mechanism of blood coagulation by non-thermal atmospheric pressure dielectric barrier discharge to evaluate the use of non-thermal plasma as a potential wound healing device in the clinic or the battlefield.

Drexel University, Philadelphia PA        Research Fellow, PhD Candidate              10/2005 – 4/2006 

1.      Studied the anisotropic mobility of non-magnetic spheres in ferrofluid for biotechnological applications like drug delivery, imaging, etc by tracking the motion of nonmagnetic microspheres immersed in ferrofluid under the influence of a uniform external magnetic field.

Drexel University, Philadelphia PA                 Graduate Research Assistant               9/2004 – 9/2005 

1.      Performed analytical modeling of NMR signal generated by solenoidal microcoil catheters using MATLAB® and elliptical integrals. Characterized the magnetic fields generated by axisymmetric solenoids as a tool for NMR spectroscopy.

 

TEACHING EXPERIENCE

Drexel University, Philadelphia PA                       Teaching Assistant                                1/2006 – 12/2009

Electrical Engineering Department: Taught undergraduate and graduate level engineering courses at Drexel University Electrical and Computer Engineering Department. My primary role was to conduct lab sessions, recitations, grade home works, quizzes and lab reports, and teach a few lectures for the following courses: Fundamentals of Intelligent Systems (Winter 06, Spring 06); Transform Methods and Filtering (Winter 07); Electronic Devices (Spring 07, Fall 07); Laboratory 4 (Summer 07, Winter 08, Summer 08); Laboratory 1 (Spring 08); Electromagnetic Fields and Waves (Fall 08); Laboratory 2 (Winter 09); Solid State Devices (graduate course) (Fall 09).

 

JOURNAL PUBLICATIONS

1.      DNA Damage in Mammalian Cells by Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma is not Mediated by Ozone, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, J. Azizkhan-Clifford and G. Friedman, Plasma Processes and Polymers, 2012. DOI:10.1002/ppap.201100156

2.      DNA Damage in Mammalian Cells by Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma is not Mediated via Lipid Peroxidation, S. Kalghatgi and J. Azizkhan-Clifford. Plasma Medicine, (Accepted for Publication)

3.      Porcine Intact and Wounded Skin Responses to Atmospheric Non-thermal Plasma, A. Wu, S. Kalghatgi, D. Dobrynin, R. Sensenig, E. Cerchar, E. Podolsky, et. al. Journal of Surgical Research, 2012. DOI 10.1016/j.jss.2012.02.039

4.      Effects of Non-Thermal Plasma on Mammalian Cells, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, G. Friedman, J. Azizkhan-Clifford. PLoS ONE, 21st January 2011. 6(1): e16270.

5.      Live Pig Tissue and Wound Toxicity of Cold Plasma Treatment, D. Dobrynin, A. Wu, S. Kalghatgi, S. Park, N. Shainsky, K. Wasko, G. Fridman, A. Brooks, G. Friedman, A. Fridman. Plasma Medicine, 2011. 1(1): p 93 – 108.

6.      Endothelial Cell Proliferation is enhanced by Low Dose Non-Thermal Plasma Treatment through Fibroblast Growth Factor-2 Release, S. Kalghatgi, A. Fridman, G. Friedman, A. Morss Clyne. Annals of Biomedical Engineering, 2010. 38 (3): p 748 – 757

7.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. N. Vasilets, A. Gutsol, A. Fridman, G. Friedman, IEEE Transactions on Plasma Science, 2007. 35(5) - pp. 1559-1566.

8.  Manipulation of Nonmagnetic Nanobeads in Dilute Ferrofluid, D. Halverson, S. Kalghatgi, B. Yellen, G. Friedman, Journal of Applied Physics, April, 2006, 99 (8): 08P504

9.  Electrical and Heat Flow Simulation of MEMS structures using SPICE, N. Naik, S. Kalghatgi, A. Ghangrekar, S. Shetty, P. R. Apte, International Journal of Computational Engineering Science, 2003, 4(2) p 397-400.

 

awards and honors

1.      Chair, Plasma Processing Science, Gordon Research Seminar, Jul 21 – 22, 2012. Smithfield, RI.

2.      Highly Commended Citation for the 2010 Drexel University Best Dissertation Award

3.      Highly Commended Citation for the 2010 Drexel University Excellence in Research Award

4.      Recipient of the 2009 Drexel University Graduate Student Outstanding Service Award

5.      Highly Commended Citation for the 2009 Drexel University Excellence in Research Award

6.      IEEE Student Travel Award, 17th IEEE International Pulsed Power Conference, Jun 29 – Jul 2 2009, Washington D.C., USA.

7.      Invited Talk at the 36th IEEE International Conference on Plasma Science, May 31 – Jun 4 2009, San Diego, CA, USA.

8.      IEEE Student Travel Award, 36th IEEE International Conference on Plasma Science, May 31 – Jun 4 2009, San Diego, CA, USA.

9.      Highly Commended Citation for the 2008 Drexel University Excellence in Research Award

10.  Drexel University 2008-09 George Hill Jr. Endowed Fellow

11.  Finalist for the Student Paper Excellence Award at the 61st Gaseous Electronics Conference, Oct 13th-17th 2008, Dallas, TX, USA.

12.  NSF Student Travel Award to attend the 61st Gaseous Electronics Conference, Oct 13th-17th 2008, Dallas, TX

13.  NSF Student Travel Award to attend Gordon Research Conference on Plasma Processing Science, Jul 13th-18th 2008 Mt. Holyoke, South Hadley, Massachusetts

14.  Best Student Paper Award at the 36th IEEE International Conference on Plasma Science, Jun 15th-19th 2008, Karlsruhe, Germany

15.  Highly Commended Citation for the 2008 Drexel University Excellence in Research Award

16.  Nominated for 2008 Drexel University Excellence in Teaching Award

17.  Recipient of the 2008 Drexel University International Travel Award

18.  Finalist for Best Student Paper Award at the 35th IEEE International Conference on Plasma Science, Albuquerque, New Mexico, Jun 16th - 22nd 2007

19.  2007 Lee Smith Travelling Fellowship for travel to 18th International Symposium on Plasma Chemistry, Kyoto, Japan

20.  IEEE Student Travel Award, 34th IEEE International Conference on Plasma Science, Albuquerque New Mexico, Jun15th - Jun19th 2007.

21.  2004 Dean’s Fellowship from Drexel University.

 

ORAL PRESENTATIONS

1.      Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Stress via a Common Mechanism in Mammalian Cells, S. Kalghatgi, J. Costello, K. Spina and J. J. Collins, BMES Annual Meeting, Oct 12th – 15th 2011, Atlanta, GA, USA

2.      Bactericidal Antibiotics Induce Oxidative Stress in Mammalian Cells via Mitochondrial Dysfunction, S. Kalghatgi, J. Costello, K. Spina and J. J. Collins, BMES Annual Meeting, Oct 12th – 15th 2011, Hartford, CT, USA

3.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated Via Lipid Peroxidation, S. Kalghatgi, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 20th International Symposium on Plasma Chemistry (ISPC 20). Jul 24th – Jul 29th 2011, Philadelphia, PA, USA

4.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated Via Lipid Peroxidation, S. Kalghatgi, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 37th IEEE International Conference on Plasma Science (ICOPS), Jun 20th – Jun 24th 2010, Norfolk, VA, USA.

5.      Non-Thermal Plasma Enhances Endothelial Cell Proliferation Through Fibroblast Growth Factor-2 Release, S. Kalghatgi, A. Fridman, Alisa Morss-Clyne, G. Friedman, 36th IEEE International Conference on Plasma Science (ICOPS), May 29th - Jun 4th 2009, San Diego, California, USA (invited).

6.      Effects of Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma Treatment on Mammalian Cells, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, G. Friedman, J. Azizkhan-Clifford, Discovery Day 2009, Drexel University College of Medicine, Oct 7th 2009, Philadelphia, PA, USA.

7.      Comparison of Different Non-Thermal Plasma Treatments of Mammalian Cells, S. Kalghatgi, C Kelly, E. Cerchar, A Fridman, J Azizkhan-Clifford, G Friedman, 36th IEEE International Conference on Plasma Science (ICOPS), May 29th - Jun 4th 2009, San Diego, California, USA.

8.      Non-Thermal Plasma Enhances Proliferation of Endothelial Cells, S. Kalghatgi, A. Fridman, Alisa Morss-Clyne, G. Friedman, 2nd International Conference on Plasma Medicine (ICPM-2), Mar 16th – Mar 20th 2009, San Antonio, TX, USA. (Invited)

9.      Toxicity of Direct Non-Thermal Plasma Treatment of Living Tissue, A.S. Wu, S. Kalghatgi, D. Dobrynin, R. Sensenig, G. Fridman, M. Balasubramanian, K. Barbee, A. Fridman, G. Friedman, A.D. Brooks, Trauma and Critical Care 6: Burns/Wound Healing, 4th Annual Academic Surgical Congress (ASC), February 3-6, 2009, Sanibel Harbor Resort, Fort Myers, FL, USA. Presented by: A. S. Wu

10.  Interaction of Non-Thermal Dielectric Barrier Discharge Plasma with DNA inside Cells (Contributed talk and selected as finalist for Student Paper Excellence Award), S. Kalghatgi, C. Kelly, G. Fridman, J. Azizkhan, A. Fridman and G. Friedman. 61st Annual Gaseous Electronics Conference, Oct 13th-Oct 17th, Dallas, TX, USA

11.  Non-Thermal Dielectric Barrier Discharge Plasma Treatment of Endothelial Cells, S. Kalghatgi, G. Fridman, A. Fridman, G. Friedman, A. Morss-Clyne, 30th International Conference of the IEEE Engineering in Medicine and Biology (EMBC), Aug 20th-Aug 24th 2008, Vancouver, Canada. Presented by: Alisa Morss Clyne

12.  Penetration of Direct Non-Thermal Plasma Treatment into Living Cells (Contributed Talk), S. Kalghatgi, C Kelly, G Fridman, A Fridman, J Azizkhan-Clifford, G Friedman, 35th IEEE International Conference on Plasma Science (ICOPS), June 15-19 2008, Karlsruhe, Germany.

13.  Toxicity of Non-Thermal Plasma Treatment of Endothelial Cells (Contributed Talk), S. Kalghatgi, G Fridman, A Fridman, A Morrs-Clyne, G Friedman, 35th IEEE International Conference on Plasma Science (ICOPS), June 15-19 2008, Karlsruhe, Germany. (Best Student Paper Award)

14.  Medical applications of direct strongly non-equilibrium plasmas, G. Friedman, G. Fridman, S. Kalghatgi , R. Sensenig, A. Shereshevsky, L. Peddinghaus, M. Balasubramanian, M. Jost, A. Brooks, D. Dobrynin, M. Cooper, A. Fridman, A. Gutsol, First International Conference on Plasma Medicine (ICPM-1), October 15th - 18th, 2007, Corpus Christi, TX. Presented by: G. Friedman.

15.  Physical and biological mechanisms of plasma interaction with living tissue, A. Fridman, G. Fridman, R. Sensenig, A. Shereshevsky, L. Peddinghaus, M. Balasubramanian, M. Jost, A. Brooks, D. Dobrynin, S. Kalghatgi, M. Cooper, A. Gutsol, G. Friedman, First International Conference on Plasma Medicine (ICPM-1), October 15th - 18th, 2007, Corpus Christi, TX. Presented by: A. Fridman.

16.  Non-thermal atmospheric plasma induces apoptosis in melanoma cancer cells, A. Brooks, G. Fridman, R. Sensenig, A. Shereshevsky, L. Peddinghaus, M. Balasubramanian, M. Jost, D. Dobrynin, S. Kalghatgi, M. Cooper, A. Fridman, A. Gutsol, G. Friedman, First International Conference on Plasma Medicine (ICPM-1), October 15th - 18th, 2007, Corpus Christi, TX. Presented by: A. Brooks.

17.  Medical applications of Floating Electrode Dielectric Barrier Discharge (FE-DBD), G. Fridman, R. Sensenig, A. Shereshevsky, L. Peddinghaus, M. Balasubramanian, M. Jost, A. Brooks, D. Dobrynin, S. Kalghatgi, M. Cooper, A. Fridman, A. Gutsol, G. Friedman, First International Conference on Plasma Medicine (ICPM-1), October 15th - 18th, 2007, Corpus Christi, TX. Presented by: G. Fridman.

18.  Medical Aspects of Plasma Interaction with Living Tissue, G. Friedman, G. Fridman, R. Sensenig, A. Shereshevsky, A.S. Wu, M.L. Peddinghaus, M. Balasubramanian, M. Jost, A. Brooks, R. Hamilton, D. Dobrynin, S. Kalghatgi, M. Cooper, A. Gutsol, A. Fridman, NATO Advanced Study Institute (ASI), Plasma Assisted Decontamination of Biological and Chemical Agents, September 16-26, 2007, Çesme, Turkey. Presented by: G. Friedman.

19.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma (Contributed Talk), S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, 34th IEEE International Conference on Plasma Science, June 17-22 2007, Albuquerque, New Mexico, USA

20.  Non-Equilibrium Dielectric Barrier Discharge Plasma Promoting Apoptotic Behavior in Melanoma Skin Cancer Cells, G. Fridman, S. Kalghatgi, A. Fridman, A. Gutsol, V. Vasilets, G. Friedman, R. Sensenig, A. Shereshevsky, M. Balasubramanian, M. Jost, A. Brooks, The 34th IEEE International Conference on Plasma Science, June 17-22, 2007, Albuquerque, New Mexico. Presented by: G. Fridman

 

PEER REVIEWED CONFERENCE PUBLICATIONS

1.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated Via Lipid Peroxidation, S. Kalghatgi, J. Azizkhan-Clifford, A. Fridman, G. Friedman, Abstracts and Full Papers, 20th International Symposium on Plasma Chemistry (ISPC 20). Jul 24th – Jul 29th 2011, Philadelphia, PA, USA

2.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated By Ozone, S. Kalghatgi, C. Kelly, E. Cerchar, J. Azizkhan-Clifford, A. Fridman, G. Friedman, Abstracts and Full Papers, 20th International Symposium on Plasma Chemistry (ISPC 20). Jul 24th – Jul 29th 2011, Philadelphia, PA, USA

3.      Cell Proliferation Following Non-Thermal Plasma Is Related To Reactive Oxygen Species Induced Fibroblast Growth Factor-2 Release, S. Kalghatgi, A. Fridman, G. Friedman, A. Morss-Clyne. In the Proceedings of the 31st International Conference of the IEEE Engineering in Medicine and Biology (EMBC), Sep 2nd- Sep 6th 2009, Minneapolis, Minnesota, USA.

4.      Low Dose Non-Thermal Plasma Interacts with Mammalian Cells Indirectly through Modification of the Cell Culture Medium, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, J. Azizkhan-Clifford, G. Friedman, Abstracts and full papers, 19th International Symposium on Plasma Chemistry, Jul 26th - July 31st 2009, Bochum, Germany.

5.      On the Interaction of Non-Thermal Atmospheric Pressure Plasma with Tissues, S. Kalghatgi, C. Kelly, E. Cerchar, R. Sensenig, A. Brooks, A. Fridman, A. Morss-Clyne, J. Azizkhan-Clifford, G. Friedman. in the Proceedings of the 17th IEEE Pulsed Power Conference (PPC), Jun 29 - Jul 2 2009, Washington D.C., USA.

6.      Toxicity of Direct Non-Thermal Atmospheric Pressure Plasma Treatment of Living Tissue, S. Kalghatgi, D. Dobrynin, A. Wu, E. Podolsky, E. Cerchar, G. Fridman, A. Fridman, A. Brooks, K. Barbee, G. Friedman. in the Proceedings of the 17th IEEE Pulsed Power Conference (PPC), Jun 29 - Jul 2 2009, Washington D.C., USA.

7.      Non-Thermal Dielectric Barrier Discharge Plasma Treatment of Endothelial Cells, S. Kalghatgi, G. Fridman, A. Fridman, G. Friedman, A. Morss-Clyne, Proceedings of the 30th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Aug 20th-Aug 24th 2008, Vancouver, Canada pp. 3578 – 3581.

8.      Penetration of Direct Non-Thermal Plasma Treatment into Living Cells, S. Kalghatgi, C. Kelly, G. Fridman, A. Fridman, J. Azizkhan-Clifford, G. Friedman, Proceedings of the IEEE 35th International Conference on Plasma Science, Jun 15th – 19th 2008, Karlsruhe, Germany.

9.      Toxicity of Non-thermal Plasma Treatment of endothelial cells, S. Kalghatgi, G. Fridman, A. Fridman, G. Friedman, A. Morss Clyne, Proceedings of the IEEE 35th International Conference on Plasma Science, Jun 15th – 19th 2008, Karlsruhe, Germany.

10.  Toxicity Analysis of Direct Nonthermal Plasma Treatment of Living Tissue, S. Kalghatgi, D. Dobrynin, A. Wu, R. Sensenig, G. Fridman, M. Balasubramanian, K. Barbee, A. Brooks, A. Fridman, G. Friedman, , Proceedings of the IEEE 35th International Conference on Plasma Science, Jun 15th – 19th 2008, Karlsruhe, Germany.

11.  Applications of Non Thermal Atmospheric Pressure Plasma in Medicine, S. Kalghatgi, D. Dobrynin, G. Fridman, M. Cooper, G. Nagaraj, L. Peddinghaus, M. Balasubramanian, K. Barbee, A. Brooks, V. Vasilets, A. Gutsol, A. Fridman, and G. Friedman, in NATO Advanced Study Institute on Plasma Assisted Decontamination of Biological and Chemical Agents (Springer, Cesme-Izmir, Turkey, 2007), p. 173.

12.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, M. Balasubramanian, G. Nagaraj, A.S. Wu, A.D. Brooks, G. Fridman, M. Cooper, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, Blood, (ASH Annual Meeting Abstracts) 2007, accepted.

13.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge, S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, In Abstracts and full papers 18th International Symposium on Plasma Science, Aug 26th-Aug31st, Kyoto University, Kyoto, Japan: Kyoto University, 2007

14.  Non-Equilibrium Dielectric Barrier Discharge Plasma Promoting Apoptotic Behavior in Melanoma Skin Cancer Cells, G. Fridman, R. Sensenig, S. Kalghatgi, A. Shereshevsky, M. Balasubramanian, A. Gutsol, V. Vasilets, A. Brooks, A. Fridman, G. Friedman, In Abstracts and full papers 18th International Symposium on Plasma Science, Aug 26th-Aug31st, Kyoto University, Kyoto, Japan: Kyoto University, 2007

15.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, Proceedings of the 34th International Conference on Plasma Science/16th Pulsed Power Plasma Symposium, Jun 16 – Jun 22nd 2007, Albuquerque, New Mexico. pp 1058-1063.

16.  Use of Ferrofluid Patterns as Diffusion Masks, Derek Halverson, Ben Yellen, S. Kalghatgi, G. Friedman, Proceedings of the Materials Research Society Spring Meeting, March 28- April 1 2005, San Francisco.

 

POSTER PRESENTATIONS

1.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated By Ozone, S. Kalghatgi, C. Kelly, E. Cerchar, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 20th International Symposium on Plasma Chemistry (ISPC 20). Jul 24th – Jul 29th 2011, Philadelphia, PA, USA

2.      Selectivity Of Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Induced Apoptosis In Malignant Cells Over Normal Cells, S. Kalghatgi, E. Cerchar, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 37th IEEE International Conference on Plasma Science (ICOPS), Jun 20th – Jun 24th 2010, Norfolk, VA, USA

3.      DNA Damage In Mammalian Cells By Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Is Not Mediated By Ozone, S. Kalghatgi, C. Kelly, E. Cerchar, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 37th IEEE International Conference on Plasma Science (ICOPS), Jun 20th – Jun 24th 2010, Norfolk, VA, USA

4.      Selectivity Of Non-Thermal Atmospheric Pressure Microsecond Pulsed Dielectric Barrier Discharge Plasma Induced Apoptosis In Malignant Cells Over Normal Cells, S. Kalghatgi, E. Cerchar, J. Azizkhan-Clifford, A. Fridman, G. Friedman, 37th IEEE International Conference on Plasma Science (ICOPS), Jun 20th – Jun 24th 2010, Norfolk, VA, USA

5.      Cell Proliferation Following Non-Thermal Plasma is Related to Reactive Oxygen Species Induced Fibroblast Growth Factor-2 Release, S. Kalghatgi, A. Fridman, G. Friedman, A. Morss-Clyne. Sep 2nd- Sep 6 2009, Minneapolis, Minnesota, USA.

6.      Low Dose Non-Thermal Plasma Interacts with Mammalian Cells Indirectly through Modification of the Cell Culture Medium, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, J. Azizkhan-Clifford, G. Friedman, 19th International Symposium on Plasma Chemistry, Jul 26th - July 31st 2009, Bochum, Germany.

7.      On the Interaction of Non-Thermal Atmospheric Pressure Plasma with Tissues, S. Kalghatgi, C. Kelly, E. Cerchar, R. Sensenig, A. Brooks, A. Fridman, A. Morss-Clyne, J. Azizkhan-Clifford, G. Friedman. 17th IEEE Pulsed Power Conference (PPC), Jun 29th - Jul 2nd 2009, Washington D.C., USA

8.      Toxicity of Direct Non-Thermal Atmospheric Pressure Plasma Treatment of Living Tissue, S. Kalghatgi, D. Dobrynin, A. Wu, E. Podolsky, E. Cerchar, G. Fridman, A. Fridman, A. Brooks, K. Barbee, G. Friedman. 17th IEEE Pulsed Power Conference (PPC), Jun 29th - Jul 2nd 2009, Washington D.C.,

9.      Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma Enhances Endothelial Cell Proliferation Via Fibroblast Growth Factor-2 Release, S. Kalghatgi, A. Fridman, G. Friedman, A. Morss-Clyne, 2009 Summer Bioengineering Conference, Jun 17th - 21st, Lake Tahoe, CA, USA.

10.  Mechanism of Induction of Apoptosis in Melanoma Cancer Cells by Non-Thermal Plasma, S. Kalghatgi, E. Cerchar, G. Fridman, A. Shereshevsky, K. Arjunan, R. Sensenig, E. Podolsky, B. Torabi, A. Fridman, A. Brooks, J. Azizkhan-Clifford, G. Friedman, 36th IEEE International Conference on Plasma Science (ICOPS), May 29th - Jun 4th 2009, San Diego, California, USA.

11.  Toxicity of direct Non-thermal Plasma Treatment of Living Tissue, D. Dobrynin, S. Kalghatgi, G. Fridman, A. Wu, E. Podolsky, K. Barbee, A. Brooks, A. Fridman, G. Friedman, 36th IEEE International Conference on Plasma Science (ICOPS), May 29th - Jun 4th 2009, San Diego, California, USA.

12.  Physical and biological mechanisms of plasma interaction with living tissue, G. Fridman, D. Dobrynin, S. Kalghatgi, A. Brooks, G. Friedman, A. Fridman, 36th IEEE International Conference on Plasma Science (ICOPS), May 29th - Jun 4th 2009, San Diego, California, USA.

13.  Mechanisms of Interaction of Non-Thermal Plasma with Mammalian Cells, S. Kalghatgi, C. Kelly, E. Cerchar, A. Fridman, J. Azizkhan-Clifford, G. Friedman, 2nd International Conference on Plasma Medicine (ICPM-2), Mar 16th – Mar 20th 2009, San Antonio, TX, USA

14.  Induction of Apoptosis by Non-thermal Plasma Treatment of Melanoma Cells, S. Kalghatgi, K. Arjunan, R. Sensenig, E. Cerchar, E. Podolsky, G. Fridman, B. Torabi, A. Fridman, A. Brooks, J. Azizkhan-Clifford, G. Friedman, 2nd International Conference on Plasma Medicine (ICPM-2), Mar 16th – Mar 20th 2009, San Antonio, TX, USA

15.  Penetration of Non-Thermal Dielectric Barrier Discharge Plasma Into Living Cells, S. Kalghatgi, C. Kelly, G. Fridman, J. Azizkhan-Clifford Azizkhan, G. Friedman, Gordon Research Conference on Plasma Processing Science, Jul 13-18th 2008, Mt. Holyoke, South Hadley, Massachusetts.

16.  Toxicity Analysis of Non-Thermal Plasma Treatment of Living Tissue, S. Kalghatgi, D. Dobrynin, R. Sensenig, A. Wu, G. Fridman, K. Barbee, Dr. M. Balasubramanian, Dr. A. Brooks, A. Fridman, G. Friedman, 35th IEEE International Conference on Plasma Science (ICOPS), June 15-19 2008, Karlsruhe, Germany.

17.  Toxicity of Non-thermal Plasma Treatment of Endothelial Cells, S. Kalghatgi, G. Fridman, A. Fridman, G. Friedman, Alisa Morss-Clyne, 35th IEEE International Conference on Plasma Science (ICOPS), June 15-19 2008, Karlsruhe, Germany.

18.  Induction of apoptosis in Melanoma Cells by Non-Thermal Atmospheric Plasma Discharge, R. Sensenig, S. Kalghatgi, G. Fridman, A. Shereshevsky, A. Brooks, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, SSO's 61st Annual Cancer Symposium, March 13-16, 2008, Chicago. USA

19.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, G. Nagaraj, S. Kalghatgi, A. Wu, G. Fridman, M. Cooper, M. Peddinghaus, M. Balasubramanian, A. Brooks, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, American Society of Hematology Annual Meeting, Dec 7-11, 2007. Atlanta. USA

20.  Mechanism of Blood Coagulation by Non-Thermal (Cold) Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, G. Fridman, G. Nagaraj, M. Cooper, M. Balasubramanian, A. Brooks, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, First International Conference on Plasma Medicine (ICPM-1), October 15th - 18th, 2007, Corpus Christi, TX.

21.  Sterilization of Living Human and Animal Tissue by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, G. Fridman, M. Cooper, D. Dobrynin, H. Ayan, A. Fridman, A. Gutsol, V. Vasilets, S. Kalghatgi, G. Friedman, A. Shereshevsky, A. Brooks, M. Peddinghaus, M. Balasubramanian, NATO Advanced Study Institute (ASI), Plasma Assisted Decontamination of Biological and Chemical Agents, September 16-26, 2007, Çesme, Turkey.

22.  Non-Equilibrium Dielectric Barrier Discharge Plasma Promoting Apoptotic Behavior in Melanoma Skin Cancer Cells, G. Fridman, S. Kalghatgi, R. Sensenig, A. Shereshevsky, R. Stoddard, G. Friedman, A. Gutsol, V. Vasilets, A. Fridman, A.D. Brooks, NATO Advanced Study Institute (ASI), Plasma Assisted Decontamination of Biological and Chemical Agents, September 16-26, 2007, Çesme, Turkey.

23.  Devices and Technological Aspects of Plasma-Medical Systems, G. Friedman, G. Fridman, H. Ayan, S. Kalghatgi, A. Fridman, A. Gutsol, NATO Advanced Study Institute (ASI), Plasma Assisted Decontamination of Biological and Chemical Agents, September 16-26, 2007, Çesme, Turkey.

24.  Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma, S. Kalghatgi, G. Fridman, M. Cooper, G. Nagaraj, M. Peddinghaus, M. Balasubramanian, V. Vasilets, A. Gutsol, A. Fridman, G. Friedman, 18th International Symposium on Plasma Chemistry, Aug 26th – Aug 31st 2007, Kyoto, Japan

25.  Non-Equilibrium Dielectric Barrier Discharge Plasma Promoting Apoptotic Behavior in Melanoma Skin Cancer Cells, G. Fridman, R. Sensenig, S. Kalghatgi, A. Shereshevsky, M. Balasubramanian, A. Gutsol, V. Vasilets, A. Brooks, A. Fridman, G. Friedman, 18th International Symposium on Plasma Chemistry, August 26 - 31, 2007, Kyoto, Japan.

 

PATENTS

1.      Plasma treatment for growth factor release from cells and tissues. S. Kalghatgi, A. Fridman, G. Friedman, Alisa Morss Clyne. March 16th 2009 - Patent electronically filed with the United States Patent & Trademark Office (U. S. Provisional Patent Application Serial No. 61/160,496)

 

LEADERSHIP ACTIVITIES AND SERVICE

Reviewer                     IEEE Transactions on Plasma Science                                                       10/2007 – Present

Reviewer                    Plasma Medicine Journal                                                                               1/2009 – Present

Reviewer                    PLOS One                                                                                                     6/2011 – Present

Treasurer                    Graduate Student Association (GSA)                                                              6/2008 – 6/2009

Responsible for allocating and managing a budget of $100,000 for all the daughter Graduate student
organizations spread over three different Drexel University campuses. Negotiated successfully with the Drexel University to award 100% Health Insurance to all Full-Time PhD Students, Implemented a campaign and fundraiser towards increasing awareness for recycling on campus, Oversight and planning of Graduate Student Day handed over to the GSA in its entirety.

Vice President            Engineering Graduate Association (EGA)                                                      6/2006 – 6/2008

Leader in a group of 500 engineering graduate students that promotes collaboration between engineering departments. Organized various seminars, socials, outings and sporting events allowing students to share research ideas, socialize in a large peer group and become actively involved in various activities on campus.

Secretary                    Engineering Graduate Association (EGA)                                                      6/2005 – 6/2006

Organized various seminars, socials, outings and sporting events allowing students to share research ideas, socialize in a large peer group and become actively involved in various activities on campus

 

PROFESSIONAL MEMBERSHIPS

Institute of Electrical and Electronic Engineers (IEEE)                                                              June 2004 – Present

American Association for Advancement of Science (AAAS)                                                            Jan 2008 – Present

Founding member of the International Society of Plasma Medicine (ISPM)                                                 Mar 2009

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Resume and Full CV

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Publications

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Areas of Research   

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Current Happenings

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